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Dual-release capsules (macrocrystals-monohydrate): Store at 15C to 30C (59F to 86F). Capsules (macrocrystals): Store at 20C to 25C (68F to 77F) dispense in tight, light-resistant container. Oral suspension: Shake vigorously before administration use within 30 days. Dual-release capsules (macrocrystals-monohydrate): Administer with food. Capsules (macrocrystals) and oral suspension: Administer with food to improve drug absorption and, in some patients, tolerance. This drug is dialyzable however, no dose adjustment guidelines have been reported. Known hypersensitivity to the active componentĬapsules (macrocrystals) and oral suspension: Safety and efficacy have not been established in patients younger than 1 month.ĭual-release capsules (macrocrystals-monohydrate): Safety and efficacy have not been established in patients younger than 12 years.Ĭonsult WARNINGS section for additional precautions. History of cholestatic jaundice/hepatic dysfunction associated with this drug Neonates younger than 1 month (because of possibility of hemolytic anemia due to immature erythrocyte enzyme systems ) Pregnant patients at term (38 to 42 weeks gestation), during labor and delivery, or when the onset of labor is imminent (because of possibility of hemolytic anemia due to immature erythrocyte enzyme systems ) Anuria, oliguria, or significant renal dysfunction (CrCl less than 60 mL/min or clinically significant elevated serum creatinine) Use: For long-term suppressive therapy Renal Dose AdjustmentsĪnuria, oliguria, or significant renal dysfunction (CrCl less than 60 mL/min or significantly elevated creatinine): Contraindicated Liver Dose Adjustments Dual-release capsules (macrocrystals-monohydrate): For the treatment of acute uncomplicated UTIs (acute cystitis) due to susceptible strains of E coli or S saprophyticus Usual Pediatric Dose for Cystitis Prophylaxisġ month or older: Doses as low as 1 mg/kg/day orally in 1 or 2 divided doses may be adequate. Dual-release capsules (macrocrystals-monohydrate): For the treatment of acute uncomplicated UTIs (acute cystitis) due to susceptible strains of E coli or S saprophyticus Usual Pediatric Dose for Urinary Tract Infection Capsules (macrocrystals) and oral suspension: For the treatment of UTIs when due to susceptible strains of E coli, enterococci, S aureus, and certain susceptible strains of Klebsiella and Enterobacter species Capsules (macrocrystals) and oral suspension: The fixed dosing recommendations are based on an average weight in each range receiving 5 to 6 mg/kg/day in 4 divided doses the adult dose is recommended for pediatric patients weighing at least 42 kg. Weight at least 42 kg: 50 to 100 mg orally 4 times a dayĭual-Release Capsules (Macrocrystals-Monohydrate):ġ2 years or older: 100 mg orally every 12 hours Weight 31 to 41 kg: 50 mg orally 4 times a day Weight 22 to 30 kg: 37.5 mg orally 4 times a day Weight 12 to 21 kg: 25 mg orally 4 times a day Weight 7 to 11 kg: 12.5 mg orally 4 times a day Use: For long-term suppressive therapy Usual Pediatric Dose for CystitisĬapsules (Macrocrystals) and Oral Suspension:ġ month or older: 5 to 7 mg/kg/day orally in 4 divided dosesįixed dosing recommendations (oral suspension): The benefits of therapy should be weighed against the potential risks (e.g., chronic pulmonary reactions). Dual-release capsules (macrocrystals-monohydrate): For the treatment of acute uncomplicated UTIs (acute cystitis) due to susceptible strains of E coli or S saprophyticus Usual Adult Dose for Cystitis ProphylaxisĬapsules (macrocrystals) and oral suspension: Reducing dose to 50 to 100 mg orally once a day at bedtime may be adequate. Dual-release capsules (macrocrystals-monohydrate): For the treatment of acute uncomplicated UTIs (acute cystitis) due to susceptible strains of E coli or S saprophyticus Usual Adult Dose for Urinary Tract Infection Capsules (macrocrystals) and oral suspension: For the treatment of UTIs when due to susceptible strains of Escherichia coli, enterococci, Staphylococcus aureus, and certain susceptible strains of Klebsiella and Enterobacter species Capsules (macrocrystals) and oral suspension: Reevaluation is needed with continued infection. Capsules (macrocrystals) and oral suspension: The lower dose is recommended for uncomplicated urinary tract infections (UTIs). Dual-release capsules (macrocrystals-monohydrate): 7 days
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Capsules (macrocrystals) and oral suspension: 1 week or at least 3 days after sterility of urine obtained Capsules (macrocrystals) and oral suspension: 50 to 100 mg orally 4 times a dayĭual-release capsules (macrocrystals-monohydrate): 100 mg orally every 12 hours